Horne, drawing upon the multi-faceted lens of Organizational Development theory and practice, examines the relationship between the human system and the entrepreneur. Horne pays particular attention to the implications of human systems as complex adaptive systems, arguing that the ultimate success of an entrepreneur is tied to their ability to work effectively and productively with, and within, complex adaptive human systems. Precisely because human systems are complex, there are no recipes or formulae that can ensure desired outcomes. But as Horne maintains, Organizational Development theory provides insights and practical tools for constructively and wisely navigating complex human systems. The author explores some of the tools and insights with respect to their relevance and value for entrepreneurs and the advancement of the entrepreneurship field.